Pyridostigmine bromide
Mestinon, Pyridostigmine, Regonol (pyridostigmine bromide) is a small molecule pharmaceutical. Pyridostigmine bromide was first approved as Mestinon on 1982-01-01. It is used to treat drug-induced abnormalities and myasthenia gravis in the USA. It is known to target cholinesterase and acetylcholinesterase.
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Commercial
Therapeutic Areas
Trade Name
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| mestinon | New Drug Application | 2020-12-02 |
| mestinon mestinon timespan | 2006-10-02 | |
| pryidostigmine bromide | ANDA | 2025-01-09 |
| pyridostigmine | ANDA | 2019-03-11 |
| pyridostigmine bromide | ANDA | 2025-06-11 |
| regonol | New Drug Application | 2022-10-13 |
Indications
FDA
EMA
No data
Agency Specific
FDA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
52 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Muscle weakness | D018908 | — | — | — | 1 | 3 | 2 | 6 | 12 |
| Myasthenia gravis | D009157 | EFO_0004991 | G70.0 | — | 1 | 3 | 2 | 5 | 11 |
| Hypotension | D007022 | EFO_0005251 | I95 | 1 | 4 | — | 1 | — | 6 |
| Orthostatic hypotension | D007024 | — | I95.1 | 1 | 3 | — | 1 | — | 5 |
| Postural orthostatic tachycardia syndrome | D054972 | — | G90.A | 2 | 2 | — | 1 | — | 5 |
| Tachycardia | D013610 | — | R00.0 | 2 | 2 | — | 1 | — | 5 |
| Syndrome | D013577 | — | — | 1 | 2 | — | 1 | — | 4 |
| Muscle relaxation | D009126 | — | — | — | — | — | 1 | 1 | 2 |
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | — | 1 | — | 1 | — | 2 |
| Hyperplasia | D006965 | EFO_0000536 | — | — | 1 | — | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | — | 1 | 1 | — | — | 1 |
| Sars-cov-2 | D000086402 | — | — | — | 1 | 1 | — | — | 1 |
| Leukemia | D007938 | — | C95 | — | — | 1 | — | — | 1 |
| Ileus | D045823 | — | K56.7 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 2 | 1 | — | — | 1 | 3 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 2 | — | — | — | 3 |
| Muscular atrophy | D009133 | — | — | — | 2 | — | — | — | 2 |
| Spinal muscular atrophy | D009134 | EFO_0003823 | G12.1 | — | 2 | — | — | — | 2 |
| Atrophy | D001284 | — | — | — | 2 | — | — | — | 2 |
| Spinal muscular atrophies of childhood | D014897 | Orphanet_83419 | G12.1 | — | 2 | — | — | — | 2 |
| Chronic fatigue syndrome | D015673 | EFO_0004540 | G93.31 | — | 2 | — | — | — | 2 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | 2 | — | — | — | 2 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 2 | — | — | — | 2 |
| Constipation | D003248 | — | K59.0 | 1 | 2 | — | — | — | 2 |
Show 28 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | — | 1 |
| Orthostatic intolerance | D054971 | — | — | 1 | — | — | — | — | 1 |
| Glycogen storage disease type ii | D006009 | Orphanet_365 | E74.02 | 1 | — | — | — | — | 1 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | — | — | — | — | 1 |
| Inflammation | D007249 | MP_0001845 | — | 1 | — | — | — | — | 1 |
| Job syndrome | D007589 | EFO_0003775 | D82.4 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuromuscular blockade | D019148 | — | — | — | — | — | — | 2 | 2 |
| Colorectal neoplasms | D015179 | — | — | — | — | — | — | 1 | 1 |
| Fatal outcome | D017809 | — | — | — | — | — | — | 1 | 1 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | — | — | — | 1 | 1 |
| Gastrointestinal motility | D005769 | — | — | — | — | — | — | 1 | 1 |
| Muscle hypotonia | D009123 | — | — | — | — | — | — | 1 | 1 |
| Diabetes complications | D048909 | — | — | — | — | — | — | 1 | 1 |
| Intraoperative complications | D007431 | — | — | — | — | — | — | 1 | 1 |
| Trismus | D014313 | — | — | — | — | — | — | 1 | 1 |
| General anesthesia | D000768 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pyridostigmine bromide |
| INN | pyridostigmine bromide |
| Description | Pyridostigmine is a pyridinium ion. |
| Classification | Small molecule |
| Drug class | cholinesterase inhibitors (physostigmine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)C(=O)Oc1ccc[n+](C)c1.[Br-] |
Identifiers
| PDB | — |
| CAS-ID | 101-26-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL812 |
| ChEBI ID | — |
| PubChem CID | 4991 |
| DrugBank | DB00545 |
| UNII ID | KVI301NA53 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
BCHE
BCHE
ACHE
ACHE
Organism
Homo sapiens
Gene name
BCHE
Gene synonyms
CHE1
NCBI Gene ID
Protein name
cholinesterase
Protein synonyms
Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, cholinesterase (serum) 2, cholinesterase 1, Pseudocholinesterase
Uniprot ID
Mouse ortholog
Bche (12038)
cholinesterase (Q543J3)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,175 adverse events reported
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